Efficient Pharmacetical Grade steroid Anastrozole Arimidex For
Anastrozole (INN) (marketed under the trade name Arimidex by
AstraZeneca) is a non-steroidal aromatase-inhibiting drug approved
for treatment of breast cancer after surgery, as well as for
metastasis in both pre and post-menopausal women.
Anastrozole is a drug used to treat breast cancer after surgery.
Anastrozole is aromatase inhibitor.Anastrozole inhibits the enzyme
aromatase,Anastrozole binds reversibly to the aromatase enzyme
through competitive inhition .Anastrozole can be used in man and
woman. Arimidex is the aromatase inhibitor of choice. Arimidex's
mechanism of action — blocking conversion of aromatizable steroids
|CAS register number||120511-73-1|
An aromatase inhibitor. Used as an antineoplastic raw materials.
Potent selective triazole aromatase inhibitors, can inhibit the
cytochrome P-450 aromatase enzyme which depends blocking the
biosynthesis of estrogen, and estrogen to stimulate breast cancer
cell growth factors. Treatment of breast cancer, especially for
those with hormone relapse after adjuvant therapy after menopause
for women with advanced breast cancer.
|Description||White crystalline powder||Complies|
Conform with standard IR
Conform with standard HPLC
|Solubility||Freely soluble in methanol,acetone,ethanol and tetrahydrofuran.And
very soluble in acetonitrile||Complies|
|Total Unspecified Impurity||max. 0.2%||0.08%|
|Individual unspecified impurlty||max. 0.1%||0.05%|
|Related compound B||max. 0.2%||0.07%|
|Related compound C||max. 0.2%||0.04%|
|Related compound D||max. 0.1%||0.05%|
|Related compound E||max. 0.1%||0.06%|
|Limit of cyclohexane||max. 0.08%||ND|
|Limit of ethylacetate||max. 0.1%||0.07%|
|Residue on ignition||max. 0.1%||0.07%|
|Storage||Cool and dry|
|Conclusion||It complies to USP32 .|
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